Relaxation of tracheal smooth muscle is impaired in innate airway hyperresponsiveness
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چکیده
منابع مشابه
Relaxation of tracheal smooth muscle is impaired in innate airway hyperresponsiveness.
The current study was designed to determine whether the nonspecific in vivo airway hyperresponsiveness of the inbred Fisher F-344 rat strain is associated with impaired spontaneous relaxation of airway smooth muscle. Strips of the posterior portion of the trachea from 10 adult Fisher and 10 adult Lewis rats were electrically stimulated at pH 7.4, 2.5 mM Ca(2+)concentration, at 37 degrees C. Bot...
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1 Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, 2725 Chemin Sainte-Foy, Québec, QC, Canada G1V 4G5 2Département de Physiologie et Biophysique, Factulté de Médecine et des Sciences de la Santé, Université de Sherbrooke, 3001 12e Avenue Nord, Sherbrooke, QC, Canada J1H 5N4 3Department of Infection, Immunity, and Inflammation, Institute for Lung Health (Glenf...
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Bronchodilators are important agents in the treatment of asthma and chronic obstructive airways disease. Beta agonists, theophyllines, and antimuscarinic agents are the main drugs in current use, but others are under investigation. Although other actions may be important, these drugs produce bronchodilation either by a direct effect on airway smooth muscle or by inhibiting neural pathways. As o...
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Four smooth muscle myosin heavy chain (SMMHC) isoforms are generated by alternative mRNA splicing of a single gene. Two of these isoforms differ by the presence [(+)insert] or absence [(-)insert] of a 7-amino acid insert in the motor domain. The rate of actin filament propulsion of the (+)insert SMMHC isoform, as measured in the in vitro motility assay, is twofold greater than that of the (-)in...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2009
ISSN: 0903-1936,1399-3003
DOI: 10.1183/09031936.00104708